Journal of Medicinal and Chemical Sciences

Three Little-known Medicinal Plants Growing in the State National Natural Park "Tarbagatai" (Republic of Kazakhstan): Their Ethnobotany, Phytochemistry, and Pharmacology

Baltabay Bekbolat Saparbayuly; Abilkassymova Alima Maratkyzy; Majitova Mariyam Akhiyatkyzy; Satmbekova Dinara Kanatovna; Datkhayev Ubaidilla Makhambetovich; Sarsenova Lazzat Kadyrgaliyevna

Volume 6, Issue 1 , January 2023, , Pages 112-120

https://doi.org/10.26655/JMCHEMSCI.2023.1.14

Abstract

The review article presents the results of studying plants growing on the territory of the State National Natural Park Tarbagatai, on the basis of which it will be possible to develop ... Read More The review article presents the results of studying plants growing on the territory of the State National Natural Park Tarbagatai, on the basis of which it will be possible to develop new medicines. In recent years, the popularity of herbal medicine, despite a great success in the creation of chemical drugs, has been growing. Interest in natural healing substances and drugs created on their basis is increasing due to both the unique properties of herbal remedies and rapidly developing research technologies in biology, medicine, and the production of drugs. The analysis and structuring of literature sources contain some information about herbal medicines, such as Corydalis ledebouriana Kar. et Kir., Malus sieversii, and Daphne altaica Pall. were carried out. They were grown in Asian countries, mainly in China and Kazakhstan. Many Corydalis species are rich in alkaloids that have a positive effect on the central nervous, digestive, cardiovascular, and pituitary-adrenal systems. Malus sieversii has a high antioxidant activity, it can inhibit cancer cell proliferation, reduce lipid oxidation, and lower cholesterol levels according to in vitro studies of animals, which may explain their roles in reducing the risk of chronic diseases. Daphne have a wide range of pharmacological activity, including anticancer, anti-inflammatory, anti-HIV, hypocholesterolemic, neurotrophic, anti-fertile, skin irritant, nematocidal activity, and pesticide activity. Phytopreparations have some advantages such as low toxicity with sufficiently high efficiency, a wide range of therapeutic action, complex organ protective effect, harmonizing effect on all organs and systems of the body, the minimum number of side effects, relative cheapness compared to synthetic drugs, and the possibility of cooking at home. Phytotherapy has some applications such as primary and secondary preventions of various diseases, health improvement, and rehabilitation of the general population under the influence of negative environmental factors, as a means of increasing the adaptive reserves of a healthy body in sports medicine.

Synthesis, Characterization, and Anti-parasitic Activity Evaluation of the Synthesized Chalcone against Toxoplasma Gondii Isolated from Cases of Abortion in Al-Najaf City

Muna Hashim Ghazzay; Samer Ali Hasan; Oun Deli Khudhair; Khalida Kadhim Abbas Al-Kelaby; Emad Sadiq Ali Al-Hilli

Volume 6, Issue 1 , January 2023, , Pages 132-141

https://doi.org/10.26655/JMCHEMSCI.2023.1.16

Abstract

Toxoplasmosis is a well-known and widespread parasite infection. Although diagnosis has come a long way, therapeutic approaches have not changed since the 1940s. Using SOCl2/EtOH as ... Read More

Periodontitis Therapy with Periodontal-derived Stem Cells (PDSCs) for Dental Tissue Regeneration

Mukhalled Salim Alasady; Abd El Hadi Kanj; Amer Kanj

Volume 6, Issue 1 , January 2023, , Pages 160-167

https://doi.org/10.26655/JMCHEMSCI.2023.1.19

Abstract

Periodontitis is a severe gum infection that can lead to tooth loss and other serious health complications. Periodontal ligament stem cells (PDLSCs), which reside in the perivascular ... Read More

Correlation between Placental Thickness and Estimated Fetal Weight in Women with Hypertension in Third Trimester: A Case Control Study

Nawar Yousif Noori Alsaegh; Ban J. Edan; Zinah Hammad

Volume 6, Issue 1 , January 2023, , Pages 168-176

https://doi.org/10.26655/JMCHEMSCI.2023.1.20

Abstract

Pregnancy-induced hypertension (PIH) as a rapid consequence of gestation consists of gestational hypertension. In this study, we decided to inspect the association between the placental ... Read More

Intravenous Pethidine versus Diclofenac Suppository in Shivering after Cesarean Section under Spinal Anesthesia

Pourya Adibi; Majid Vatankhah; Bibi Mona Razavi; Farnaz Fendereski; Mehrdad Malekshoar

Volume 5, Issue 7 , November and December 2022, , Pages 1142-1149

https://doi.org/10.26655/JMCHEMSCI.2022.7.1

Abstract

Introduction: One of the most common surgeries on women is a cesarean section. Shivering is a prevalent adverse effect of spinal anesthesia following surgery. This study aimed to evaluate ... Read More

Post Cesarean Section Analgesic Effects of Intravenous Pethidine and Diclofenac Suppository after Spinal Anesthesia: A Randomized Clinical Trial

Pourya Adibi; Majid Vatankhah; Mehrdad Malekshoar; Bibi Mona Razavi; Tayyebeh Zarei

Volume 5, Issue 7 , November and December 2022, , Pages 1150-1155

https://doi.org/10.26655/JMCHEMSCI.2022.7.2

Abstract

Introduction: One of the most difficult challenges after a C-section is minimizing pain. The goal of this study was to see how intravenous pethidine and diclofenac suppository altered ... Read More

The Effect of Heat Variable on the Chemical Composition and Bioactivities of a Citrullus lanatus Seed Aqueous Extracts

Noora Thamer Abdulaziz; Yasser Fakri Mustafa

Volume 5, Issue 7 , November and December 2022, , Pages 1166-1176

https://doi.org/10.26655/JMCHEMSCI.2022.7.4

Abstract

Citrullus lanatus (Citrullus L.) co-products have been shown in multiple studies to have biological attributes, attempting to make them a naturally-derived source for medicinal products. ... Read More

Characteristics of Last Lumps Outbreak in Maysan: Incidence, Demographic Factors, and Mumps-Related Complication

Sadiq Musa Ahmed; Hmood Madhi Hasan

Volume 5, Issue 7 , November and December 2022, , Pages 1183-1190

https://doi.org/10.26655/JMCHEMSCI.2022.7.6

Abstract

Mumps is a viral infection and one of acute disease caused by virus type called a paramyxovirus. This infection is characterized by many signs and symptoms such as salivary glands (one ... Read More

Identification of Genetic Markers of Drug Resistance and Virulence Factor Gene in Campylobacter Jejuni Isolated From Children in North Iraq

Baydaa Ghanim Mohammed

Volume 5, Issue 7 , November and December 2022, , Pages 1191-1199

https://doi.org/10.26655/JMCHEMSCI.2022.7.7

Abstract

Campylobacter(C)spp. are curved, Gram-negative. They are common prevalent causes of zoonotic disease. C.jejuni and C.coli are responsible of about 90% of Campylobacteriosis, associated ... Read More

Psychological and Moral Factors for Elderly in Their Adaptation to Surgical Procedures: A Quasi-Experimental Study

Mahmood Hasen Shuhata Alubiady

Volume 5, Issue 7 , November and December 2022, , Pages 1200-1207

https://doi.org/10.26655/JMCHEMSCI.2022.7.8

Abstract

Most people fear surgery, even if it may save lives. Patients may fear hospitalization for surgery, causing anxiety. Preoperative nerves are prevalent. The main objective is to assess ... Read More

Echocardiographic Assessment of the Aortic Stenosis Valve Area: Parameters and Outcome

Ameen Abdulhasan Al Alwany

Volume 5, Issue 7 , November and December 2022, , Pages 1281-1288

https://doi.org/10.26655/JMCHEMSCI.2022.7.17

Abstract

Background: Among individuals who have a stenotic aortic valve, a precise assessment of aortic valve area is essential for clinical judgment. So far, no studies have been conducted ... Read More

A Preliminary Protocol for Induction of Tuberculosis Spondylitis by Mycobacterium Tuberculosis Strain H37R: In-vivo New Zealand White Rrabbits Model

Otman Siregar; Aznan Lelo; . Rahyussalim; Syafruddin Ilyas; . Benny; Tri Kurniawati; Yohanes Augustinus; . Hendra; Tommy Mandagi; Muhammad Luqman Labib Zufar

Volume 5, Issue 7 , November and December 2022, , Pages 1299-1310

https://doi.org/10.26655/JMCHEMSCI.2022.7.19

Abstract

Background: Proper animal model is a critical prerequisite of any experimental study, while it is a lack for tuberculosis spondylitis. This study aimed to validate a protocol for induction ... Read More

Evaluation of the Fetal Thigh Cross-Section to Predict Fetal Birth Weight in Normal-Term Pregnant Women

Hadeel Ali Mahamda; Essraa Hameed Humadi

Volume 5, Issue 7 , November and December 2022, , Pages 1311-1320

https://doi.org/10.26655/JMCHEMSCI.2022.7.20

Abstract

Background: Fetal weight is an important factor in assessing fetus growth, and arranging for delivery. Different parameters and different models were used to estimate fetal weight, ... Read More Background: Fetal weight is an important factor in assessing fetus growth, and arranging for delivery. Different parameters and different models were used to estimate fetal weight, and the 3-dimensional ultrasound plays a crucial role in many aspects, including assessing the fetus's weight.Aim of the study: To precisely assess third-trimester ultrasound using fetal limb cross-section area by 3D ultrasound to predict birth weight of the fetus versus sonographic parameters for predicted fetal weight by two-dimensional ultrasound.Materials and methods: This Prospective-cohort study recruited one hundred pregnant women with a normal pregnancy in their late third trimester. They were taken from the antenatal clinic and had their fetal weights estimated by two-dimensional ultrasound by Modified Hadlock (MH) and three-dimensional ultrasound by measuring the thickness of the soft tissue of thigh, assessment of fetal weight, and follow up to delivery to measure the actual birth weight of the infant and comparing the results. A study was done in the department of Obstetrics and Gynecology at Al-Yarmouk Teaching Hospital.The Ethical Committee code was obtained after getting the scientific approval.Results: One hundred pregnant women were enrolled in this study, their mean age of the women was ‎‎32.6 years old, their mean BMI was 25.6 kg/m2, and most of them had a cephalic ‎presentation (92%); in the current study, Modified Hadlock overestimate fetal weight 159.9 g, while midthigh soft tissue thickness (MTSTT) underestimates the fetal weight - 67.3 gm. Modified Hadlock was non significantly different from zero. In terms of systemic errors, there was a non-significant difference between MH from zero, whereas MTSTT significantly differs from MH., and in terms of absolute error, the 3D model was significantly different from MH. Conclusion: ‎This study found that compared with using the traditional Hadlock's formula, the fetal thigh soft tissue thickness measured by the novel method of three-dimensional ultrasonography is more precisely and specifically related to the antenatal anticipated birth weight.

Transforming Health Care Services through Knowledge Management during COVID-19 in India

Lakshmi Prasad Padhy; Ipseeta Satpathy; B. Chandra Mohan Patnaik

Volume 5, Issue 6 , November and December 2022, , Pages 900-914

https://doi.org/10.26655/JMCHEMSCI.2022.6.4

Abstract

Knowledge management (KM) is considered to be an important intervention in improving health care services. KM facilitates the transfer of the existing knowledge and the development ... Read More

Early Renal Effects of Chronic Co-Exposure to a Mixture of Toxic Metals in two Pediatric Age Groups

Jawhar Laamech; Abdelkader Jalil El Hangouche; Youssra Amekran; Said Bakkali; Saad Chakkor

Volume 5, Issue 6 , November and December 2022, , Pages 943-953

https://doi.org/10.26655/JMCHEMSCI.2022.6.8

Abstract

Sources of contamination by lead (Pb), cadmium (Cd), and mercury (Hg) are not regulated in Morocco, and have been reported to be responsible for renal effects in two separate cohorts ... Read More

The in vitro Effects of New Albocarbon-based Coumarins on Blood Glucose-controlling Enzymes

Sarah Ahmed Waheed; Yasser Fakri Mustafa

Volume 5, Issue 6 , November and December 2022, , Pages 954-967

https://doi.org/10.26655/JMCHEMSCI.2022.6.9

Abstract

The majority of the world’s most hazardous pathologies are linked to the oxidative damaging effect of free moieties. One of the diseases associated with these damaging radicals ... Read More The majority of the world’s most hazardous pathologies are linked to the oxidative damaging effect of free moieties. One of the diseases associated with these damaging radicals is diabetes. This disease is widely distributed among people of all ages, with the elderly being the most affected. Therefore, it is essential to conduct comprehensive investigations in order to promote the creation of the novel free radical-housing and hypoglycemic compounds. This study involves the synthesis of eight novel albocarbon-based coumarins, which were confirmed by various spectrophotometers. Their hypoglycemic and free radical-housing effects were analyzed. The pharmacokinetic profile was checked in silico using pre-ADMET, known as a free online program. The hypoglycemic influence was tested against two types of the blood glucose-controlling enzymes. In addition, the new compounds’ potency index was measured. The free radical-housing potential was analyzed by testing these coumarins’ ability to scavenge DDPT and hydroxyl harmful radicals. Pharmacokinetic studies demonstrated that the synthesized albocarbon-based coumarins penetrate the gastrointestinal mucosa very well, and the majority of these compounds penetrate the blood-brain barrier only slightly. These findings suggest the good oral bioavailability along with low neurological toxicity profiles. The investigation of the hypoglycemic influence of these new compounds revealed that they had a less potent enzyme inhibition capacity compared to the standard, with LY5 being the most powerful one. Besides, the assessment of the free radical-housing potential of these synthesized albocarbon-based coumarins also indicated that all of them were less active than the reference. Among them, LY0 was the strongest free radical-housing compound from these recognitions, along with the safety and good pharmacokinetic parameters in accordance with the computer-based study. The researchers believed that these new albocarbon-based coumarins can be applied for the creation of new successful drugs with hypoglycemic and free radical-housing effects which can help in the modulation of much serious pathology.

Phytochemical Analysis and Antimicrobial Evaluation of Quince Seeds’ Extracts

Eman Tareq Mohammed; Raghad Riyadh Khalil; Yasser Fakri Mustafa

Volume 5, Issue 6 , November and December 2022, , Pages 968-979

https://doi.org/10.26655/JMCHEMSCI.2022.6.10

Abstract

Microbial infection and microbial resistance to the classical antibiotics have been immense challenges which portend the health of societies. This has directed researchers to straight ... Read More

A Comparative Study on the Effects of Propofol and Thiopental on the Apgar score of Neonates Undergoing Cesarean Section under General Anesthesia: A Systematic Review Study

Seyed Ebrahim Sadeghi; Mehrdad Malekshoar; Majid Vatankhah; Pourya Adibi; Elham Rahmanian; Mohammad Sadegh Sanie Jahromi; Maryam Nemati

Volume 5, Issue 6 , November and December 2022, , Pages 1008-1017

https://doi.org/10.26655/JMCHEMSCI.2022.6.14

Abstract

Introduction: Apgar score of neonates at birth is one of the determinants of postnatal mortality and one of the effective factors in Apgar score of cesarean section neonates that is ... Read More Introduction: Apgar score of neonates at birth is one of the determinants of postnatal mortality and one of the effective factors in Apgar score of cesarean section neonates that is the type of drug used for maternal anesthesia. Owing to the disagreement on the benefits and possible side effects of anesthetics, the present study was an attempt to evaluate and compare the effects of propofol and thiopental on the Apgar score of neonates undergoing cesarean section under the general anesthesia.Methods: The present study is a systematic review. Persian articles were searched in databases such as SID, Iranmedex, Magiran, and English articles were searched in databases such as Science Direct, PubMed, ProQuest, Cochrane Library, Embase, Scopus, and Google Scholar search engine without any time limitation. To access the full text of articles, the keywords of propofol, thiopental, general anesthesia, neonatal Apgar score, cesarean section, and their combination, the Boolean search methods, and conjunctions of “And” and “Or” were used. The information of reviewed articles included the first author, year of publication, the country of study, the sample size, and the outcome of the study.Results: A total of 27 articles were included to the study. In 22 studies, no statistically significant difference was found between thiopental and propofol effects on neonatal Apgar score at minutes 1 and 5. Also, in 4 studies, Apgar scores at minutes 1 and 5 were reported higher in the propofol group than the thiopental group. Furthermore, in one study, Apgar score at minute 1 was reported higher in the propofol group than the thiopental group. In three studies, Apgar score of neonates at the minute 1 in thiopental group was reported higher than the propofol group.Conclusion: It seems that neonates whose mothers underwent the general anesthesia with propofol for cesarean section have better Apgar scores than those who received thiopental. One of the effects of propofol is its shorter duration of action, and if the patient has a problem with difficult intubation, the effect of the drug ends sooner and the patient’s breathe returns as soon as possible. Likewise in this regard, compared to thiopental, which has a longer effect, Propofol is a more effective drug in cesarean section women under the general anesthesia.

Stress in University Teachers in the Framework of the Post-Pandemic Face-To-Face Academic Resumption

Elmer Benito Rivera Mansilla; Roxana Yolanda Castillo-Acobo; Elena Guillermina Martinez Puma; Yuselino Maquera Maquera; Jose Luis Arias Gonzales; Mario Mario Jose Vasquez-Pauca

Volume 5, Issue 6 , November and December 2022, , Pages 1040-1047

https://doi.org/10.26655/JMCHEMSCI.2022.6.17

Abstract

Teachers in America returned to work in September 2020 to a climate of fear and uncertainty due to the country’s first-ever government lockdown due to the Covid-19 pandemic. Since ... Read More Teachers in America returned to work in September 2020 to a climate of fear and uncertainty due to the country’s first-ever government lockdown due to the Covid-19 pandemic. Since the outbreak of the epidemic, teachers around the world have been building up psychological symptoms due to various factors which have accompanied the pandemic, these factors have resulted in a significant amount of stress, depression, and anxiety, among the other factors in teachers and this study is done to determine that how these factors affect teachers especially after the pandemic. They had to use online teaching throughout the lockdown, and now that schools are reopening, they have exhibited a lot of anxiety about the new and the unprecedented teaching environment. According to the findings of the study, females had the highest stress response with a mean of 7.11 and a standard deviation of 4.414, while males had lower stress level with a mean of 4.99 and a standard deviation of 2.32. The results of t-test also revealed that there was a significant stress in teachers at 5 percent level of significance (p-value = 0.000, df = 1549, and t-test= 2.28). On work stability, many respondents chose NO with a mean of 8.79 and a standard deviation of 5.309 implying that after Covid-19, the work stability of teachers had been affected and adapting to the new normal was difficult and had not only for students, but also for the teachers. Anxiety was another variable that was taken into consideration in this study and further, females had the highest response with a mean of 7.01 and a standard deviation of 4.53, on the other hand, males had a lower response of 4.53, the study proved the significance of the test that teachers are affected by anxiety during this period at 5% level of significance and p-value of 2.28. Finally, depression as a variable was further determined to be significance (p-value = 0.000, df = 1549, and t-test = 2.28) by the study. Therefore, the study concluded that, having school-aged children, being a victim of Covid-19 or having a relative affected by the virus increases stress, depression, and anxiety levels in teachers especially in female teachers. Teachers who have children are more likely to be stressed out because they have to cope with a hefty workload and at the same time, the burden of caring for their families. These professionals had to deal with the twin whammy of returning to school for themselves and for their children. Family life may have contributed to the elevated anxiety levels during the pandemic, as raising a family during crisis times can include the additional challenges, such as managing finances, child care, and home education obligations.

Evaluation of In vitro Antioxidant and Antidiabetic Properties of Cydonia Oblonga Seeds' Extracts

Raghad Riyadh Khalil; Eman Tareq Mohammed; Yasser Fakri Mustafa

Volume 5, Issue 6 , November and December 2022, , Pages 1048-1058

https://doi.org/10.26655/JMCHEMSCI.2022.6.18

Abstract

There is an unequivocal relationship between oxidative stress and diabetes development, progression, or both. In recent years, some novel bioactive compounds derived from plants have ... Read More

Formulation, Characterization and In vitro Evaluation of Dual-Drug Loaded Biomimetic Chitosan-Collagen Hybrid Nanocomposite Scaffolds

Vyshnavi Tallapaneni; Lavanya Mude; Divya Pamu; Veera Venkata Satyanarayana Reddy Karri

Volume 5, Issue 6 , November and December 2022, , Pages 1059-1074

https://doi.org/10.26655/JMCHEMSCI.2022.6.19

Abstract

BackgroundDiabetes Mellitus (DM) is one of the most concerning conditions, and its chronic complications are nearly synonymous with inflammation, oxidative stress, and infections. In ... Read More

Investigating the Effect of Oral Clonidine on Surgeon Satisfaction from Surgical Field in Septorhinoplasty

Mojtaba Ghaedi; Lohrasb Taheri; Mojtaba Sohrabpour; Navid Kalani; Mohammad Sadegh Sanie Jahromi

Volume 5, Issue 6 , November and December 2022, , Pages 1085-1093

https://doi.org/10.26655/JMCHEMSCI.2022.6.21

Abstract

Introduction: Haemorrhage during septorhinoplasty surgery is challenging for the surgeons since it can reduce the visibility of the surgical site. Thus, the present study aimed to investigate ... Read More

Relationship between Psychological Distress and Physical Activity among Medical Students: A Cross-Sectional Study

Abdelkader Jalil El Hangouche; Jawhar Laamech; Youssra Amekran; Saad Chakkor; Said Bakkali; Nora Taiek; Narjisse Damoun

Volume 5, Issue 6 , November and December 2022, , Pages 1132-1141

https://doi.org/10.26655/JMCHEMSCI.2022.6.25

Abstract

Medical studies are known to be a source of psychological distress and radical changes in medical students’ behaviors and attitudes. We carried out this study to assess the prevalence ... Read More

Asthma Recurrent in Children: Parental Knowledge Along with Medical Treatment

. Irdawati; Mutia Chandra Permata Sury

Volume 5, Issue 5 , September and October 2022, , Pages 667-675

https://doi.org/10.26655/JMCHEMSCI.2022.5.2

Abstract

Children, like adults, are not immune to asthma and may develop the disease. Obviously, children face specific challenges and difficulties that can cause shortness of breath and disruption ... Read More

A Review on Dental Material with Regard to Biocompatibility Properties

Noor Hafida Widyastuti; Aulia Rizky Nurwita

Volume 5, Issue 5 , September and October 2022, , Pages 695-702

https://doi.org/10.26655/JMCHEMSCI.2022.5.4

Abstract

The use of dental materials in the human mouth is not possible except by relying on physiological, biological, pathological studies and the study of physical, mechanical, and chemical ... Read More

Volume 7 (2024)

Volume 6 (2023)

Volume 5 (2022)

Volume 4 (2021)

Volume 3 (2020)

Volume 2 (2019)

Volume 1 (2018)

Main Subjects = Pharmaceutical sciences

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